Anxiolytic β-Carbolines: From Molecular Biology to the by David N. Stephens PDF

By David N. Stephens

ISBN-10: 0387571442

ISBN-13: 9780387571447

ISBN-10: 3642784534

ISBN-13: 9783642784538

because the discovery a few 15 years in the past of benzodiazepine
modulatory websites linked to GABA A receptors, great
effort has long gone into figuring out their molecular
pharmacology and into constructing new anxiolytic medicines that
interact selectively with them. sought after during this research
has beenthe discovery that ~-carbolines, a different
chemical classification from benzodiazepines, additionally act at these
receptors yet that their results are occasionally quite
different from these of the benzodiazepines.This book
documents the newest discoveries within the molecular
biology of the GABA A receptor and divulges how
an integration of the result of examine inmolecular
biology, artificial chemistry, biochemical and behavioral
pharmacology, and scientific pharmacology has paved the way
forthe improvement of ~-carbolines from elements inducing
anxiety and convulsions to a singular remedy for anxiety
states, attaining a behavioral selectivity via selective
actions at subtypes of receptors.

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Anxiolytic β-Carbolines: From Molecular Biology to the Clinic (Psychopharmacology Series) by David N. Stephens

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